FREEDOM represents the evolution of a previous study conducted by our research group (Deprair), which aimed to assess the impact of air pollution on the severity of Major Depressive Disorder and to explore the potential biological mechanisms underlying this relationship. With FREEDOM, we aim to investigate the role of green spaces in modulating the severity of mood disorders.
From a biological perspective, the study will also further examine the role of extracellular vesicles—small particles released into the bloodstream by various cell types, including neurons—which enable communication between distant organs.
The value of the Deprair study lies in its ability to integrate environmental, clinical, and mental health data to build a clear picture of the impact of air pollution on the human psyche. The findings raised awareness within the scientific community, highlighting the urgent need to identify potential protective factors and mitigation strategies.
It is precisely from this need that the FREEDOM project has taken shape: a natural continuation that does not seek to replace Deprair, but rather to complement it—broadening its scope and integrating new variables into the research process.
Our research group intends to continue investigating the relationship between the natural environment and mental health over time. We began with Major Depression due to its high prevalence in the population and its significant impact on disability, but the relationship between the natural environment and other disorders—such as anxiety or schizophrenia—could also be explored further.
Associate Professor of Occupational Medicine, Department of Clinical and Community Sciences, University of Milan. Occupational Physician, "Luigi Devoto" Occupational Health Clinic, Occupational Medicine Unit, IRCCS Ca’ Granda Foundation, Ospedale Maggiore Policlinico
Postdoctoral Research Fellow, Department of Clinical and Community Sciences, University of Milan
Coordinator for Dissemination Strategy and Interpretation of Mental Health Data. Associate Professor of Psychiatry, Department of Medical-Surgical and Transplant Physiopathology, University of Milan. Consultant Psychiatrist, Department of Neurosciences and Mental Health, IRCCS Ca’ Granda Foundation, Maggiore Policlinico Hospital
Full Professor of Forest Management and Silviculture, University of Bari Aldo Moro
This study analyzes the relationship between air pollution and content of neuron-derived extracellular vesicles in a population of patients with depression.
This study analyzes the effect of green spaces on the severity of Major Depressive Disorder, highlighting a protective effect.